![]() ![]() ACE2 receptors are expressed in human ovaries, while angiotensin has been detected in measurable amounts in the follicular fluid. Along the same lines, SARS-CoV-2 may affect oocyte performance through mechanisms that increase oxidative stress.Īs SARS-CoV-2 acts through the angiotensin-converting enzyme 2 (ACE2) receptor, this was proposed as an additional pathway affecting ovaria follicles and oocytes. Based on this pathogenic pathway, it can be hypothesized that SARS-CoV-2 could increase sperm DNA fragmentation, which might affect fertilizing potential. This mechanism has been blamed to cause male infertility through a reduction of progressive motility in spermatozoa and a simultaneous increase in sperm DNA fragmentation. SARS-CoV-2 seems to be far more aggressive in terms of severe illness, morbidity and mortality in comparison to common influenzas, thus it is reasonable to hypothesize a possible substantial effect of Covid-19 on fertility.Īt the cellular level, common influenza viruses promote oxidant-sensitive pathways, leading to increased oxidative stress. ![]() Previous studies have already shown an association between influenza and infertility. Why Should I Register and Submit Results?Īlthough there is as yet no scientific evidence that a SARS-CoV-2 virus infection could have negative effects on fertility, currently the possibility that the virus could affect sperm function and egg performance cannot be excluded. ![]()
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